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Tuesday, July 21, 2020 | History

1 edition of Target Organ Toxicity: Immune system found in the catalog.

Target Organ Toxicity: Immune system

Target Organ Toxicity: Immune system

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Published by U.S. Dept. of Health and Human Services in Research Triangle Park, NC .
Written in English

    Subjects:
  • Toxicology.,
  • Organs (Anatomy).,
  • Immunity.

  • Edition Notes

    Other titlesProceedings of the immune system symposium.
    StatementCo-sponsored by Society of Toxicology and National Institute of Environmental Health Sciences.
    SeriesEnvironmental health perspectives -- v. 43., DHHS publication -- no. (NIH) 82-218.
    The Physical Object
    Pagination[vii], 171 p. :
    Number of Pages171
    ID Numbers
    Open LibraryOL15139038M

      This new edition of our bestselling book, Lu's Basic Toxicology, provides a number of key benefits that make it a must-read for toxicology specialists worldwide, including:Revision of a Bestseller - the new Sixth Edition provides the critical updates toxicologists need to keep up with the changing timesNew Information - on over-the-counter preparat. Lu's basic toxicology: fundamentals, target organs, and risk assessment. Target organs and systems --Toxicology of the liver --Toxicology of the kidney --Toxicology of the immune system --Respiratory system toxicology Mechanisms of toxic effects -- Modifying factors of toxic effects -- Conventional toxicity studies -- Systems.

      Target organ toxicity: immune system. Arlington, Virginia, October , 1 Find the latest peer-reviewed research articles and preprints on Coronavirus here.   The gastrointestinal system and its link to the immune system. Upon oral exposure, which is the most relevant route of exposure to cyanobacterial metabolites [], gastrointestinal epithelia are the first barrier to be overcome before systemic exposure, and hence, the gastrointestinal tract is a major entry portal for cyanobacteria and their bioactive metabolites into an organism’s system.

    ISBN: OCLC Number: Description: x, pages: illustrations ; 23 cm: Contents: General considerations --Absorption, distribution, and excretion of toxicants --Biotransformation of toxicants --Toxic effects --Modifying factors of toxic effects --Conventional toxicity studies --Carcinogenesis --Mutagenesis --Developmental toxicology --Lactation --Toxicology.   Immunological (Immune System) The immune system consists of white blood cells, the thymus, the spleen, lymph nodes, and lymph channels. It provides immunity to the body from bacteria, viruses, parasites, and tumors by producing B lymphocyteand T lymphocyte cells). Also, the immune system helps the body distinguish its own cells and tissues from.


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Target Organ Toxicity: Immune system Download PDF EPUB FB2

Abstract. Recently, interest has centered on the immune system as a target organ for toxic effects. This seems a reasonable choice, since it can be argued that alterations induced in this system as a result of a toxic insult could lead to impaired by:   The respiratory system is both a target organ and a portal of entry for toxicants.

Asthma morbidity and death from asthma are increasing. More than toxicants cause asthma, and many more can exacerbate it [Rom ]. A large number of xenobiotics and occupations are associated with the development of work-aggravated and work-related asthma. The Toxicology of Fishes book. The Toxicology of Fishes.

DOI link for The Toxicology of Fishes. The Immune System of Fish: A Target Organ of Toxicity. elasmobranchs, and chondrosteans have been studied in attempts to elucidate the evolution of the vertebrate immune system.

Also, species such as salmonids (: Richard T. Di Giulio, David E. Hinton. The chapter introduces the structure and function of the immune system and the underlying reasons for why and how it can be a target organ for toxicity.

Chemical exposure may cause a reduction in the circulating mature blood cells, or effects on the bone marrow. The Target Organ Toxicology Series reviews the morphology, physiology, biochemistry, cellular biology, and developmental aspects of various target organs.

Topics covered by books in the series include the incidence of chemically induced human disease related to the organ system, the reliability of laboratory data, methods used to estimate human risks, chemicals that adversely affect specific. Book Description This classic textbook now enters its forth edition, offering a distillation of decades of research and teaching experience in toxicology.

Known all over the world after its translation into six languages, Lu's Basic Toxicology: Fundamentals, Target Organs, and Risk Assessment is a benchmark text that brings clarity and insight. sure to a substance of low toxicity or an acute exposure to a highly toxic chemical may alter immunological functions and predispose an indi-vidual to increased disease susceptibility.

In prac-tice, however, documenting such effects is not the easy task one would hope for. This is due to the nature of the immune system, which comprises a large.

Immunotoxicity is toxicity of the immune system. It can take several forms: Hypersensitivity (allergy and autoimmunity) The kidney is highly susceptible to toxicants because a high volume of blood flows through the organ and it filters large amounts of toxins which can concentrate in the kidney tubules.

It is noteworthy that oral intake of lead by rats at a dose of 10 ppm, which does not otherwise damage their health, has been demonstrated to suppress immunity (Koller et al., a,b).

Thus, the immune system of rodents appears to be a sensitive target organ of lead toxicity. Liver and the kidney are considered as ideal target organs for assessing the in vitro organ toxicity of nanoparticles considering involvement of these organs in accumulation, processing and clearance of the latter.

The liver plays an important role in the reticuloendothelial clearance of nanoparticles by the phagocytic Kupfer cells. Nevertheless, such interactions are difficult to predict and assessments should be based on data from testing of the relevant mixtures and by measuring a wide array of molecular biomarkers of target organ toxicity and nonspecific biomarkers of toxic response (oxidative stress, DNA.

Abstract. Recently, interest has centered on the immune system as a target organ for toxic effects. This seems a reasonable choice, since it can be argued that alterations induced in this system as a result of a toxic insult could lead to impaired immunity.

The discussion of biomarkers in biological or organ systems is particularly useful for an understanding of some issues relating to key toxicity endpoints for the nervous system, cardiovascular system, respiratory system, ocular system, gastrointestinal system, skeletal system, immune system, placenta, blood and bone marrow, kidney, liver and.

from book An Introduction to Toxicology (pp) Target-Organ Toxicity: Liver and Kidney pro- and anti-inflammatory cascades of the innate immune system are simultaneously activated, the.

Toxic responses can manifest systemically (e.g., the immune system) or may produce specific toxic effects in a single organ system (skin) or single organ (liver). Organ toxicity may therefore result from a direct and primary effect on a target organ or as a result of secondary effects in organs and tissues that have a physiological dependence.

The target organs for cadmiu m toxicity in animals include the liver, kidney, lungs, testes, prostate, hear t, skeletal s ystem, nervous s ystem and immune sy stem.

However, prolonged huma n. Recently, interest has centered on the immune system as a target organ for toxic effects. This seems a reasonable choice, since it can be argued that alterations induced in this system as a result of a toxic insult could lead to impaired immunity.

Such an alteration may be. Handbook of Toxicology of Chemical Warfare Agents, Second Edition covers every aspect of deadly toxic chemicals used in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this essential reference offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors and.

An overview of the immune system is presented, and an example of one possible tier system of assays is described. Introduction As a target organ for toxicity the immune system is, at first glance, a logical choice to investigate.

One could reason that prolonged expo-sure to a substance of low toxicity. Recognition by regulatory agencies that the immune system is an important, as well as sensitive, target organ for chemical- and drug-induced toxicity is another.

Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism. Toxicity can refer to the effect on a whole organism, such as an animal, bacterium, or plant, as well as the effect on a substructure of the organism, such as a cell (cytotoxicity) or an organ such as the liver (hepatotoxicity).By extension, the word may be metaphorically used to.The Globally Harmonized System for Classification and Labeling of Chemicals (GHS) provides guidance for the classification of substances that cause “specific target organ/systemic toxicity arising from a repeated exposure” (Part 3, Chapter ).

The GHS classification is based on the weight of evidence from all data, including published.In some instances, individuals can have unpredictable reactions, or idiosyncratic responses, to a drug or other idiosyncratic response is uncommon, and it is sometimes impossible to understand whether it is the result of a genetic predisposition or has some other cause such as the status of the immune system.